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Effects of vitamin D on the placental proteomic profile

ABSTRACT: We studied the effects of vitamin D on the placental proteomic profile

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Placenta

SUBMITTER: Antigoni Manousopoulou

LAB HEAD: Spiros D. Garbis

PROVIDER: PXD011443 | Pride | 2022-04-01

REPOSITORIES: Pride

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Publications

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit.

Ashley Brogan B Simner Claire C Manousopoulou Antigoni A Jenkinson Carl C Hey Felicity F Frost Jennifer M JM Rezwan Faisal I FI White Cory H CH Lofthouse Emma M EM Hyde Emily E Cooke Laura D F LDF Barton Sheila S Mahon Pamela P Curtis Elizabeth M EM Moon Rebecca J RJ Crozier Sarah R SR Inskip Hazel M HM Godfrey Keith M KM Holloway John W JW Cooper Cyrus C Jones Kerry S KS Lewis Rohan M RM Hewison Martin M Garbis Spiros D D SDD Branco Miguel R MR Harvey Nicholas C NC Cleal Jane K JK

eLife 20220308

Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships between maternal 25(OH)D and fetal physiology. We demonstrate active placental uptake of 25(OH)D3 by endocytosis, placental metabolism of 25(OH)D3 into 24,25-dihydroxyvitamin D3 and active 1,25-dihydroxyvitamin D [1, ...[more]

PMID: 35256050

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