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Peptidomics profiling of biopsies from the human jejunum before and after gastrectomy

ABSTRACT: Profiling of the human jejunum peptidome before and after total gastrectomy. The study compares the peptidome of jejunum using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, Motilin somatostatin and neurotensin amongst others.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Jejunum

SUBMITTER: Richard Kay

LAB HEAD: Professor Fiona Gribble

PROVIDER: PXD011498 | Pride | 2019-02-15

REPOSITORIES: Pride

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Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie Pierre P Roberts Geoffrey P GP McGavigan Anne K AK Kay Richard G RG Li Joyce J Leiter Andrew A Melvin Audrey A Biggs Emma K EK Ravn Peter P Davy Kathleen K Hornigold David C DC Yeo Giles S H GSH Hardwick Richard H RH Reimann Frank F Gribble Fiona M FM

Cell reports 20190201 6

Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely reported, but the importance of GLP-1 in post-bariatric physiology remains debated. Here, we show that GLP-1 is a major driver of insulin secretion after bariatric surgery, as demonstrated by blocking GLP-1 receptors (GLP1Rs) post-gastrectomy in lean hum ...[more]

PMID: 30726726

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