Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Koshi Imami
LAB HEAD: Matthias Selbach
PROVIDER: PXD011518 | Pride | 2018-12-07
REPOSITORIES: Pride
Ciolli Mattioli Camilla C Rom Aviv A Franke Vedran V Imami Koshi K Arrey Gerard G Terne Mandy M Woehler Andrew A Akalin Altuna A Ulitsky Igor I Chekulaeva Marina M
Nucleic acids research 20190301 5
The proper subcellular localization of RNAs and local translational regulation is crucial in highly compartmentalized cells, such as neurons. RNA localization is mediated by specific cis-regulatory elements usually found in mRNA 3'UTRs. Therefore, processes that generate alternative 3'UTRs-alternative splicing and polyadenylation-have the potential to diversify mRNA localization patterns in neurons. Here, we performed mapping of alternative 3'UTRs in neurites and soma isolated from mESC-derived ...[more]