Identification of HIPs in the islets of mice and non-diabetic human donors

ABSTRACT: Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD) mice, BALB/c mice, and non-diabetic human donors by mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Pancreatic Islet, Islet Of Langerhans

DISEASE(S): Disease Free

SUBMITTER: Timothy Wiles  

LAB HEAD: Thomas Delong

PROVIDER: PXD011606 | Pride | 2019-01-07

REPOSITORIES: Pride