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Role of Fbxo7 in dopaminergic neurons

ABSTRACT: Analysis of a conditional knockout of Fbxo7/Park15 expression in mouse brains.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Dopaminergic Neuron

DISEASE(S): Parkinson's Disease

SUBMITTER: Heike Laman

LAB HEAD: Heike Laman

PROVIDER: PXD011666 | Pride | 2019-08-28

REPOSITORIES: Pride

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Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway.

Stott Simon Rw SR Randle Suzanne J SJ Al Rawi Sara S Rowicka Paulina A PA Harris Rebecca R Mason Bethany B Xia Jing J Dalley Jeffrey W JW Barker Roger A RA Laman Heike H

The Journal of pathology 20190806 2

The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with both sporadic Parkinson's disease and a severe form of autosomal recessive early-onset Parkinsonism. Here we report that conditional deletion of Fbxo7 in the midbrain dopamine neurons results in an early reduction in striatal dopamine levels, together with a slow, progressive loss of midbr ...[more]

PMID: 31144295

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