Dataset Information
The circadian clock components BMAL1 and Rev-Erb regulate flavivirus replication
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte, Cell Culture
SUBMITTER: 
Abhinav Kumar
LAB HEAD: Prof. Nicole Zitzmann
PROVIDER: PXD011721 | Pride | 2019-11-12
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 50cm-26062018_CA04.mgf | Mgf | |||
| 50cm-26062018_CA04.raw | Raw | |||
| 50cm-26062018_CA06.mgf | Mgf | |||
| 50cm-26062018_CA06.raw | Raw | |||
| 50cm-26062018_CA09.mgf | Mgf |
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Publications
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication.
Nature communications 20190122 1
The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the ...[more]
