Interference of RNA molecules with protein aggregation in vitro.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Hela Cell
SUBMITTER: 
Giulia Calloni
LAB HEAD: R. Martin Vabulas
PROVIDER: PXD011751 | Pride | 2019-09-13
REPOSITORIES: Pride
Publications
RNA structure drives interaction with proteins.
Sanchez de Groot Natalia N Armaos Alexandros A Graña-Montes Ricardo R Alriquet Marion M Calloni Giulia G Vabulas R Martin RM Tartaglia Gian Gaetano GG
Nature communications 20190719 1
The combination of high-throughput sequencing and in vivo crosslinking approaches leads to the progressive uncovering of the complex interdependence between cellular transcriptome and proteome. Yet, the molecular determinants governing interactions in protein-RNA networks are not well understood. Here we investigated the relationship between the structure of an RNA and its ability to interact with proteins. Analysing in silico, in vitro and in vivo experiments, we find that the amount of double- ...[more]
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