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Exosomes - Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria

ABSTRACT: Quantitative Proteomic analysis of human plasma exosomes using TMT isobaric tag labelling and nanoLC-Orbitrap. Nine patient samples and five control samples are analyzed to assess the proteome changes due to the pathology

OTHER RELATED OMICS DATASETS IN: GSE122352

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Plasma Cell, Extracellular Exosome Assembly

DISEASE(S): Paroxysmal Nocturnal Hemoglobinuria

SUBMITTER: Pol Herrero

LAB HEAD: Irene Martínez Martínez

PROVIDER: PXD011768 | Pride | 2019-03-12

REPOSITORIES: Pride

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Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria.

Teruel-Montoya Raúl R Luengo-Gil Ginés G Vallejo Fernando F Yuste José Enrique JE Bohdan Nataliya N García-Barberá Nuria N Espín Salvador S Martínez Constantino C Espín Juan Carlos JC Vicente Vicente V Martínez-Martínez Irene I

Scientific reports 20190305 1

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a clonal disease of blood cells caused by the lack of glycosyl phosphatidyl inositol anchored proteins bound to the cell membrane. In consequence, erythrocytes lead to intravascular hemolysis upon complement activation, which promotes high risk of thrombosis, intravascular hemolytic anemia, and bone marrow failure in patients. The mechanisms of thrombosis in PNH are still poorly understood. Treatment with eculizumab reduces intravascular hemolysis and ...[more]

PMID: 30837665

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