Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Petra Beli
LAB HEAD: Petra Beli
PROVIDER: PXD011772 | Pride | 2019-08-19
REPOSITORIES: Pride
Hildebrandt Andrea A Brüggemann Mirko M Rücklé Cornelia C Boerner Susan S Heidelberger Jan B JB Busch Anke A Hänel Heike H Voigt Andrea A Möckel Martin M MM Möckel Martin M MM Ebersberger Stefanie S Scholz Anica A Dold Annabelle A Schmid Tobias T Ebersberger Ingo I Roignant Jean-Yves JY Zarnack Kathi K König Julian J Beli Petra P
Genome biology 20191022 1
<h4>Background</h4>Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products. Translating ribosomes that encounter poly(A) sequences are terminally stalled, followed by ribosome recycling and decay of the truncated nascent polypeptide via ribosome-associated quality control.<h4>Results</h4>Here, we demonstrat ...[more]