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SPIO corona - Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

ABSTRACT: Identification of corona proteins in serum and plasma of healthy donors

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Blood Serum

SUBMITTER: Dmitri Simberg

LAB HEAD: Dmitri Simberg

PROVIDER: PXD011781 | Pride | 2019-01-14

REPOSITORIES: Pride

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Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles.

Vu Vivian P VP Gifford Geoffrey B GB Chen Fangfang F Benasutti Halli H Wang Guankui G Groman Ernest V EV Scheinman Robert R Saba Laura L Moghimi Seyed Moein SM Simberg Dmitri D

Nature nanotechnology 20190114 3

Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonization of superparamagnetic iron oxide (SPIO) nanoworms with the third complement protein (C3) was dependent on the biomolecule corona of the nanoparticles. Here we show that natural antibodies play a critical rol ...[more]

PMID: 30643271

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