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Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart

ABSTRACT: Placental Cdx2 cells can be isolated and utilized for cardiac regeneration in a mouse model of myocardial infarction with evidence of multipotentiality both in vitro and in vivo

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Placenta

SUBMITTER: Niveda Sundararaman

LAB HEAD: Dr. Jennifer Van Eyk

PROVIDER: PXD011783 | Pride | 2019-05-09

REPOSITORIES: Pride

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Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.

Vadakke-Madathil Sangeetha S LaRocca Gina G Raedschelders Koen K Yoon Jesse J Parker Sarah J SJ Tripodi Joseph J Najfeld Vesna V Van Eyk Jennifer E JE Chaudhry Hina W HW

Proceedings of the National Academy of Sciences of the United States of America 20190520 24

The extremely limited regenerative potential of adult mammalian hearts has prompted the need for novel cell-based therapies that can restore contractile function in heart disease. We have previously shown the regenerative potential of mixed fetal cells that were naturally found migrating to the injured maternal heart. Exploiting this intrinsic mechanism led to the current hypothesis that Caudal-type homeobox-2 (Cdx2) cells in placenta may represent a novel cell type for cardiac regeneration. Usi ...[more]

PMID: 31109997

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