Proteomics

Dataset Information

0

Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV

ABSTRACT: Neutrophil Extracellular Traps (NETs) are chromatin-derived extracellular structures that are expelled from neutrophils in response to infectious or inflammatory stimuli. NET DNA structures are decorated with proteins including histones, myeloperoxidase and neutrophil elastase. NETs are implicated in the development of auto-immunity in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalisation of intracellular neoepitopes e.g. dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy individuals, and from patients with RA and SLE.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neutrophil, Blood

DISEASE(S): Systemic Lupus Erythematosus,Rheumatoid Arthritis

SUBMITTER: Deborah Simpson  

LAB HEAD: Dr Helen L Wright

PROVIDER: PXD011796 | Pride | 2019-02-18

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus.

Chapman Elinor A EA   Lyon Max M   Simpson Deborah D   Mason David D   Beynon Robert J RJ   Moots Robert J RJ   Wright Helen L HL  

Frontiers in immunology 20190311

Neutrophil Extracellular Traps (NETs) are implicated in the development of auto-immunity in diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalization of intracellular neoepitopes e.g., dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy controls, and from patients with RA and SLE to determine if NETs  ...[more]

Similar Datasets

Genomics RNA externalized by neutrophil extracellular traps promotes inflammatory pathways in endothelial cells
2023-07-31 | GSE160143 | GEO
Proteomics The cytosolic DNA sensor cGAS recognizes Neutrophil Extracellular Traps
2021-02-18 | PXD015579 | Pride
Proteomics Neutrophil extracellular traps in the central nervous system: a novel therapeutic target in pneumococcal meningitis.
2019-11-12 | PXD011546 | Pride
Proteomics Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
2017-03-31 | MSV000080847 | MassIVE
Proteomics Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
2017-01-23 | PXD005688 | Pride
Transcriptomics Human lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
Proteomics Data in support of Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
2021-09-08 | PXD010723 | Pride
Proteomics NET induced by different stimuli: a comparative proteomic analysis
2019-07-15 | PXD012951 | Pride
Proteomics Neutrophils from patients with recurring Panton-Valentine Leukocidin-positive Staphylococcus aureus infections are more sensitive to PVL induced NETosis
2023-11-23 | PXD025702 | Pride
Transcriptomics In the aftermath of stroke or myocardial infarction, neutrophil extracellular traps disrupt systemic immunoglobulin production
2024-03-17 | GSE254410 | GEO