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ITRAQ experiment to identify proteins that changed before and after NMT1 was knocked down in both Bel-7402 and Bel-7404 cells

ABSTRACT: We performed proteomics isobaric tags for relative and absolute quantification (iTraq) to identify proteins that changed before and after NMT1 was knocked down in both Bel-7402 and Bel-7404 cells.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Guoqing Zhu

LAB HEAD: Fenyong Sun

PROVIDER: PXD011812 | Pride | 2021-09-08

REPOSITORIES: Pride

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N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis <i>via</i> Differentially Regulating Ubiquitination of Targets.

Zhu Guoqing G Wang Feng F Li Haojie H Zhang Xiao X Wu Qi Q Liu Ya Y Qian Mingping M Guo Susu S Yang Yueyue Y Xue Xiangfei X Sun Fenyong F Qiao Yongxia Y Pan Qiuhui Q

Frontiers in oncology 20210531

<h4>Background</h4>A tremendous amount of studies have suggested that post-translational modifications (PTMs) play pivotal roles during tumorigenesis. Compared to other PTMs, lipid modification is less studied. Recently, N-myristoylation, one type of lipid modification, has been paid attention to the field of cancer. However, whether and how N-myristoylation exerts its roles in liver tumorigenesis still remains unclear.<h4>Methods</h4>Parallel reaction monitoring (PRM) was conducted to evaluate ...[more]

PMID: 34136404

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