HEK293T MS - Representing dynamic biological networks with multi-scale probabilistic models

ABSTRACT: As an example of a comprehensive model of signal transduction, we provide a Wnt network that shows remarkable robustness under a range of phenotypical and pathological conditions. Its simulation allows the clarification of controversially discussed molecular mechanisms of Wnt signalling by predicting wet-lab measurements. A loss of Rac1 (Ras-related C3 botulinum toxin substrate 1) or JNK2 affected the TCF/LEF reporter whereas a loss of JNK1 had only mild effects, likely due to low abundance of JNK1.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Kidney

SUBMITTER: Johann Kraus  

LAB HEAD: Hans A. Kestler

PROVIDER: PXD011835 | Pride | 2019-11-12

REPOSITORIES: Pride