Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: Antonia Piazzesi
LAB HEAD: Daniele Bano
PROVIDER: PXD011851 | Pride | 2019-02-13
REPOSITORIES: Pride
Gioran Anna A Piazzesi Antonia A Bertan Fabio F Schroer Jonas J Wischhof Lena L Nicotera Pierluigi P Bano Daniele D
The EMBO journal 20190222 6
Aberrant mitochondrial function contributes to the pathogenesis of various metabolic and chronic disorders. Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Using an unbiased multi-omics approach, we report here that IIS inhibition reduces protein synthesis and favors catabolism in mitochondrial deficient <i>Caenorhabditis elegans</i> W ...[more]