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Integrative analysis of phenotype and testicular quantitative proteome of CKLF-like MARVEL transmembrane domain-containing protein 4 (CMTM4) deficiency mouse reveal its association with male fertility

ABSTRACT: iTRAQ quantitative proteome of wild and CMTM4 knockout mouse testis tissue.Integrative analysis of phenotype and testicular quantitative proteome of CKLF-like MARVEL transmembrane domain-containing protein 4 (CMTM4) deficiency mouse reveal its association with male fertility.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Epithelial Cell

DISEASE(S): Disease Free

SUBMITTER: Mingchao Wang

LAB HEAD: wang mingchao

PROVIDER: PXD011936 | Pride | 2019-03-18

REPOSITORIES: Pride

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Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility.

Liu FuJun F Liu XueXia X Liu Xin X Li Ting T Zhu Peng P Liu ZhengYang Z Xue Hui H Wang WenJuan W Yang XiuLan X Liu Juan J Han WenLing W

Molecular & cellular proteomics : MCP 20190313 6

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family that has been implicated in male reproduction. CMTM4 is an evolutionarily conserved member that is highly expressed in the testis. However, its function in male fertility remains unknown. Here, we demonstrate that CMTM4 is associated with spermatogenesis and sperm quality. Using Western blotting and immunohistochemical analyses, we found CMTM4 expression to be decreased in poor-quality hum ...[more]

PMID: 30867229

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