Dataset Information

Proteomic Analysis of Intermediate Uveitis

ABSTRACT: Liquid vitreous biopsies were collected from two groups: eyes from control subjects (n=4) undergoing pars plana vitrectomy to remove an idiopathic macular hole (IMH), and eyes from test subjects (n=4) with IU. Vitreous samples were analyzed using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach for relative quantitation and protein identification.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vitreous Humor, Matrix-based Tissue

DISEASE(S): Intermediate Uveitis

SUBMITTER: Vinit Mahajan

LAB HEAD: Vinit Mahajan

PROVIDER: PXD011972 | Pride | 2022-02-22

REPOSITORIES: Pride

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Publications

Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target.

Sepah Yasir J YJ Velez Gabriel G Tang Peter H PH Yang Jing J Chemudupati Teja T Li Angela S AS Nguyen Quan D QD Bassuk Alexander G AG Mahajan Vinit B VB

American journal of ophthalmology case reports 20200306

<h4>Purpose</h4>To profile vitreous protein expression of intermediate uveitis (IU) patients.<h4>Observations</h4>We identified a mean of 363 ± 41 unique proteins (mean ± SD) in IU vitreous and 393 ± 69 unique proteins in control samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of liquid vitreous biopsies collected during pars plana vitrectomy. A total of 233 proteins were differentially expressed among control and IU samples, suggesting a protein signature that c ...[more]

PMID: 32274442

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Dataset Information

Proteomic Analysis of Intermediate Uveitis

Publications

Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target.

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