BALF secretome and exosome proteomics
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Bronchoalveolar Lavage
SUBMITTER: 
Yingxin Zhao
LAB HEAD: Yingxin Zhao, Ph.D.
PROVIDER: PXD012060 | Pride | 2019-07-16
REPOSITORIES: Pride
Publications
Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.
Zhao Yingxin Y Tian Bing B Sun Hong H Zhang Jing J Zhang Yueqing Y Ivannikov Maxim M Motamedi Massoud M Liu Zhiqing Z Zhou Jia J Kaphalia Lata L Calhoun William J WJ Maroto Rosario R Brasier Allan R AR
Journal of proteomics 20190610
Small molecule inhibitors of the epigenetic regulator bromodomain-containing protein 4 (BRD4) are potential therapeutics for viral and allergen-induced airway remodeling. A limitation of their preclinical advancement is the lack of detailed understanding of mechanisms of action and biomarkers of effect. We report a systems-level pharmacoproteomics in a standardized murine model of toll-like receptor TLR3-NFκB/RelA innate inflammation in the absence or presence of a highly selective BRD4 inhibito ...[more]
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