Heat shock dependent proteome changes in HEK293 chromatin proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Gerhard Mittler
LAB HEAD: Gerhard Mittler
PROVIDER: PXD012077 | Pride | 2022-04-07
REPOSITORIES: Pride
Publications
Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1.
Antonova Aneliya A Hummel Barbara B Khavaran Ashkan A Redhaber Desiree M DM Aprile-Garcia Fernando F Rawat Prashant P Gundel Kathrin K Schneck Megan M Hansen Erik C EC Mitschke Jan J Mittler Gerhard G Miething Cornelius C Sawarkar Ritwick R
Cell reports 20191101 6
Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding. Their function in the cytosol has been well studied. Notably, chaperones are also present in the nucleus, a compartment where proteins enter after completing de novo folding in the cytosol, and this raises an important question about chaperone function in the nucleus. We performed a systematic analysis of the nuclear pool of heat-shock protein 90. Three orthogonal and independent analyses led us to the core function ...[more]
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