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Equine energy-storing SDFT tendon development, Proteomic analysis of IFM and fascicles through development

ABSTRACT: Equine energy-storing SDFT tendon development, Proteomic analysis of IFM and fascicles through development

INSTRUMENT(S): Q Exactive

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Tendon

SUBMITTER: Danae Zamboulis

LAB HEAD: Peter Clegg

PROVIDER: PXD012169 | Pride | 2021-09-08

REPOSITORIES: Pride

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Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix.

Zamboulis Danae E DE Thorpe Chavaunne T CT Ashraf Kharaz Yalda Y Birch Helen L HL Screen Hazel Rc HR Clegg Peter D PD

eLife 20201016

Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However, the temporal nature and drivers of functional adaptation remain undefined. Here, we explore functional adaptation and specialisation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which the collagen (fascicle) ...[more]

PMID: 33063662

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