Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Paramecium Tetraurelia
SUBMITTER: Guillaume Arras
LAB HEAD: Damarys Loew
PROVIDER: PXD012170 | Pride | 2019-06-26
REPOSITORIES: Pride
Frapporti Andrea A Miró Pina Caridad C Arnaiz Olivier O Holoch Daniel D Kawaguchi Takayuki T Humbert Adeline A Eleftheriou Evangelia E Lombard Bérangère B Loew Damarys D Sperling Linda L Guitot Karine K Margueron Raphaël R Duharcourt Sandra S
Nature communications 20190620 1
In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3-9 enzymes, while H3K27me3 is catalyzed by the SET-domain Enhancer-of-zeste enzymes, which are the catalytic subunits of Polycomb Repressive Complex 2 (PRC2). Here, we show that the Enhancer-of-zeste-like protein Ezl1 from the unicellular eukaryote Paramecium tetraurelia, which exhibits significant sequence and structural similar ...[more]