Proteomics

Dataset Information

0

P. aeruginosa PAO1 and ΔodsR (ΔPA2076) strains


ABSTRACT: We carried out globlal proteomics analysis on P. aeruginosa PAO1 and ΔodsR (ΔPA2076) strains to determine differences following treatment with OA, 10-HOME, or 7,10-DiHOME oxylipin vs non-treated controls.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Pseudomonas Aeruginosa Pao1

TISSUE(S): Cell Suspension Culture, Endospore

DISEASE(S): Disease Free

SUBMITTER: james mobley  

LAB HEAD: Javier Campos Gomez

PROVIDER: PXD012256 | Pride | 2019-02-25

REPOSITORIES: Pride

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Publications

Oxylipins mediate cell-to-cell communication in <i>Pseudomonas aeruginosa</i>.

Martínez Eriel E   Cosnahan Rachael K RK   Wu Mousheng M   Gadila Shiva K SK   Quick Eric B EB   Mobley James A JA   Campos-Gómez Javier J  

Communications biology 20190215


Oxygenated unsaturated fatty acids, known as oxylipins, are signaling molecules commonly used for cell-to-cell communication in eukaryotes. However, a role for oxylipins in mediating communication in prokaryotes has not previously been described. Bacteria mainly communicate via quorum sensing, which involves the production and detection of diverse small molecules termed autoinducers. Here we show that oleic acid-derived oxylipins produced by <i>Pseudomonas aeruginosa</i> function as autoinducers  ...[more]

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