Dataset Information
Mouse Lung Mannose-6-Phosphate Glycoproteome LC-MSMS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung
SUBMITTER: 
Junfeng Huang
LAB HEAD: Lingjun LI
PROVIDER: PXD012403 | Pride | 2020-03-11
REPOSITORIES: Pride
Publications
Dual-Functional Titanium(IV) Immobilized Metal Affinity Chromatography Approach for Enabling Large-Scale Profiling of Protein Mannose-6-Phosphate Glycosylation and Revealing Its Predominant Substrates.
Analytical chemistry 20190822 18
Mannose-6-phosphate (M6P) glycosylation is an important post-translational modification (PTM) and plays a crucial role in transferring lysosomal hydrolases to lysosome, and is involved in several other biological processes. Aberrant M6P modifications have been implicated in lysosomal storage diseases and numerous other disorders including Alzheimer's disease and cancer. Research on profiling of intact M6P glycopeptides remains challenging due to its extremely low stoichiometry. Here we propose a ...[more]
