Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Alexander Haupt
LAB HEAD: Prof. Dr. Bernd Fakler
PROVIDER: PXD012487 | Pride | 2019-11-13
REPOSITORIES: Pride
Nature communications 20190322 1
GABA<sub>B</sub> receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs. Of the three interacting proteins, selectively the genetic loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression. Proteomic and functional analyses revealed ...[more]