Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Erythrocyte
SUBMITTER: Alexander Schmidt
LAB HEAD: Alexander Schmidt
PROVIDER: PXD012490 | Pride | 2022-02-24
REPOSITORIES: Pride
Nature communications 20200612 1
The nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We show that NSD1 knockdown alters erythroid clonogenic growth of human CD34<sup>+</sup> hematopoietic cells. Ablation of Nsd1 in the hematopoietic system of mice induces a transplantable erythroleukemia. In vitro differentiation of Nsd1<sup>-/-</sup> erythroblasts is majorly impaired despite abundant expression of GATA1, the transcriptional master regulator of erythropoiesi ...[more]