Dataset Information
Proteomic Analysis of Diaphragm after Chronic Heart Failure_Males
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Diaphragm
DISEASE(S): Acute Myocardial Infarction
SUBMITTER: 
Brian McDonagh
LAB HEAD: Brian McDonagh
PROVIDER: PXD012500 | Pride | 2020-04-15
REPOSITORIES: Pride
Publications
Diaphragm weakness and proteomics (global and redox) modifications in heart failure with reduced ejection fraction in rats.
Journal of molecular and cellular cardiology 20200205
Inspiratory dysfunction occurs in patients with heart failure with reduced ejection fraction (HFrEF) in a manner that depends on disease severity and by mechanisms that are not fully understood. In the current study, we tested whether HFrEF effects on diaphragm (inspiratory muscle) depend on disease severity and examined putative mechanisms for diaphragm abnormalities via global and redox proteomics. We allocated male rats into Sham, moderate (mHFrEF), or severe HFrEF (sHFrEF) induced by myocard ...[more]
