Dataset Information

USP7: combing tools towards selectivity

ABSTRACT: Active-site probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new selective reagents.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Román González-Prieto

LAB HEAD: Alfred C.O. Vertegaal

PROVIDER: PXD012535 | Pride | 2019-03-13

REPOSITORIES: Pride

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Publications

USP7: combining tools towards selectivity.

Gjonaj Lorina L Sapmaz Aysegul A González-Prieto Román R Vertegaal Alfred C O ACO Flierman Dennis D Ovaa Huib H

Chemical communications (Cambridge, England) 20190401 35

Active-site directed probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new selective reagents. ...[more]

PMID: 30972393

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Dataset Information

USP7: combing tools towards selectivity

Publications

USP7: combining tools towards selectivity.

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