Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Manal Alsulami
LAB HEAD: Gerard Cagney
PROVIDER: PXD012549 | Pride | 2019-06-13
REPOSITORIES: Pride
Alsulami Manal M Munawar Nayla N Dillon Eugene E Oliviero Giorgio G Wynne Kieran K Alsolami Mona M Moss Catherine C Ó Gaora Peadar P O'Meara Fergal F Cotter David D Cagney Gerard G
Molecular & cellular proteomics : MCP 20190510 7
SETD1A is a SET domain-containing methyltransferase involved in epigenetic regulation of transcription. It is the main catalytic component of a multiprotein complex that methylates lysine 4 of histone H3, a histone mark associated with gene activation. In humans, six related protein complexes with partly nonredundant cellular functions share several protein subunits but are distinguished by unique catalytic SET-domain proteins. We surveyed physical interactions of the SETD1A-complex using endoge ...[more]