A mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori

ABSTRACT: We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserved vaccine candidates, some of which we exemplarily validate.

INSTRUMENT(S):

ORGANISM(S): Helicobacter Pylori J99 (campylobacter Pylori J99)

SUBMITTER: Mario Oroshi  

LAB HEAD: Felix Meissner

PROVIDER: PXD012566 | Pride | 2019-11-11

REPOSITORIES: Pride