Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Ovary
SUBMITTER: Tamar Geiger
LAB HEAD: Tamar geiger
PROVIDER: PXD012574 | Pride | 2020-06-02
REPOSITORIES: Pride
Persi Erez E Prandi Davide D Wolf Yuri I YI Pozniak Yair Y Barnabas Georgina D GD Levanon Keren K Barshack Iris I Barbieri Christopher C Gasperini Paola P Beltran Himisha H Faltas Bishoy M BM Rubin Mark A MA Geiger Tamar T Koonin Eugene V EV Demichelis Francesca F Horn David D
Proceedings of the National Academy of Sciences of the United States of America 20190806 34
Repetitive sequences are hotspots of evolution at multiple levels. However, due to difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content, beyond microsatellites, in proteomes and genomes directly from proteomic and genomic raw data. This method was applied to a wide range of tumors and normal tissues. We identify high similarity between repeat ...[more]