Proteomics

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The protein expression landscape of the heart across humans and model organisms

ABSTRACT: Here we perform a global analysis of cardiac protein expression in humans and model organisms across cardiac chambers using quantitative mass spectrometry based proteomics. We measure >6,500 proteins in each species and create a global comparison of cardiac protein expression across species. The data was collected in an online database for access by cardiac researchers. This data will enable researchers to e. g. choose the best model organism for a scientific question at hand, facilitate transfer of knowledge between studies conducted in different model organisms and help to integrate knowledge of cardiac physiology and disease to point to new leads in cardiac research.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat) Equus Caballus (horse) Homo Sapiens (human) Danio Rerio (zebrafish) (brachydanio Rerio) Sus Scrofa Domesticus (domestic Pig) Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Ulrike Leurs  

LAB HEAD: Alicia Lundby

PROVIDER: PXD012636 | Pride | 2021-02-03

REPOSITORIES: Pride

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Publications

Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in cardiac protein expression between humans and model organisms. Proteins immediately determine cellular function, yet their large-scale investigation in hearts has lagged behind those of genes and transcripts. Here, we set out to bridge this knowledge gap  ...[more]

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