Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Macrophage
SUBMITTER: Zon Weng Lai
LAB HEAD: Tobias Walther
PROVIDER: PXD012640 | Pride | 2021-09-08
REPOSITORIES: Pride
Mejhert Niklas N Kuruvilla Leena L Gabriel Katlyn R KR Elliott Shane D SD Guie Marie-Aude MA Wang Huajin H Lai Zon Weng ZW Lane Elizabeth A EA Christiano Romain R Danial Nika N NN Farese Robert V RV Walther Tobias C TC
Molecular cell 20200204 6
Lipid droplets (LDs) store lipids for energy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulate lipid storage in macrophages, a cell type involved in metabolic diseases. Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic process ...[more]