Deciphering functions of VHL in Clear Cell Renal Cell Carcinoma

ABSTRACT: VHL is the most frequently mutated gene in ccRCC.It functions via the oxygen-dependent ubiquitin-mediated degradation of hypoxia-inducible factor (HIF). The stabilization and hyperactivation of HIF1 play essential roles in tumorigenesis. This is a TMT based proteomics experiment aimed to investigate the functions of VHL in ccRCC systematically.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Renal Clear Cell Carcinoma

SUBMITTER: Songbiao Zhu  

LAB HEAD: Haiteng Deng

PROVIDER: PXD012665 | Pride | 2023-01-05

REPOSITORIES: Pride