Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Renal Clear Cell Carcinoma
SUBMITTER: Songbiao Zhu
LAB HEAD: Haiteng Deng
PROVIDER: PXD012665 | Pride | 2023-01-05
REPOSITORIES: Pride
Zhu Songbiao S Ding Wenxi W Chen Yuling Y Wang Weixuan W Xu Renhua R Liu Chongdong C Liu Xiaohui X Deng Haiteng H
Genomics, proteomics & bioinformatics 20210227 4
Clear cell renal cell carcinoma (ccRCC) is a frequently occurring renal cancer. The Von Hippel-Lindau disease tumor suppressor VHL, a known tumor suppressor gene, is frequently mutated in about 50% of patients with ccRCC. However, it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL. In the present study, we found that higher expression of VHL was correlated with the better disease-free survival (DFS) in ccRCC patients using The Cancer Genome Atlas (TCGA) ...[more]