Proteomics

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Arsenic induces reversible nitrosative stress and behavioural changes in mice

ABSTRACT: Studies on exposure of mice to Arsenic, combined with unique tools developed in our laboratory to determine the consequences of NO formation in mouse brain and neuronal cell culture, will probe mechanistic pathways of nitrosative damage operable in behavioural development.

INSTRUMENT(S): orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Haitham Amal  

LAB HEAD: Steven Tannenbaum

PROVIDER: PXD012691 | Pride | 2021-09-08

REPOSITORIES: Pride

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Publications

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide.

Amal Haitham H   Gong Guanyu G   Yang Hongmei H   Joughin Brian A BA   Wang Xin X   Knutson Charles G CG   Kartawy Maryam M   Khaliulin Igor I   Wishnok John S JS   Tannenbaum Steven R SR  

International journal of molecular sciences 20200531 11

<h4>Background</h4>Accumulating public health and epidemiological literature support the hypothesis that arsenic in drinking water or food affects the brain adversely.<h4>Methods</h4>Experiments on the consequences of nitric oxide (NO) formation in neuronal cell culture and mouse brain were conducted to probe the mechanistic pathways of nitrosative damage following arsenic exposure.<h4>Results</h4>After exposure of mouse embryonic neuronal cells to low doses of sodium arsenite (SA), we found tha  ...[more]

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