Contribution of ShkA dysregulation to the cdG0 phenotype
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Caulobacter Sp. 736
TISSUE(S): Cell Suspension Culture, Permanent Cell Line Cell
SUBMITTER: 
Alexander Schmidt
LAB HEAD: Alexander Schmidt
PROVIDER: PXD012739 | Pride | 2019-12-16
REPOSITORIES: Pride
Publications
Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter.
Kaczmarczyk Andreas A Hempel Antje M AM von Arx Christoph C Böhm Raphael R Dubey Badri N BN Nesper Jutta J Schirmer Tilman T Hiller Sebastian S Jenal Urs U
Nature communications 20200210 1
Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise gene expression during G1/S transition in Caulobacter crescentus. We show that c-di-GMP stimulates the kinase ShkA by binding to its central pseudo-receiver domain, activates the TacA transcription factor, and initiates a G1/S-specific transcription ...[more]
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