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Qualitative and Quantitative proteomic analyses of Schistosoma japonicum Eggs and Egg-derived Secretory-Excretory proteins

ABSTRACT: Schistosome parasites lay up to a thousand eggs per day inside the veins of their mammalian hosts. The immature eggs deposited by females against endothelia of venules will embryonate within days. Approximately 30% of the eggs will migrate to the lumen of the intestine to continue the parasite life cycle. Many eggs, however, are trapped in the liver and intestine causing the main pathology associated with schistosomiasis mansoni and japonica, the liver granulomatous response. Excretory/Secretory egg proteins drive much of egg-induced pathogenesis of schistosomiasis mansoni, and Schistosoma japonicum induce a markedly distinct granulomatous response to that of S. mansoni.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Candida Albicans (yeast)

TISSUE(S): Egg

SUBMITTER: Carolina De Marco Verissimo

LAB HEAD: Malcolm K. Jones

PROVIDER: PXD012835 | Pride | 2019-09-26

REPOSITORIES: Pride

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Qualitative and quantitative proteomic analyses of Schistosoma japonicum eggs and egg-derived secretory-excretory proteins.

De Marco Verissimo Carolina C Potriquet Jeremy J You Hong H McManus Donald P DP Mulvenna Jason J Jones Malcolm K MK

Parasites & vectors 20190416 1

<h4>Background</h4>Schistosome parasites lay up to a thousand eggs per day inside the veins of their mammalian hosts. The immature eggs deposited by females against endothelia of venules will embryonate within days. Approximately 30% of the eggs will migrate to the lumen of the intestine to continue the parasite life-cycle. Many eggs, however, are trapped in the liver and intestine causing the main pathology associated with schistosomiasis mansoni and japonica, the liver granulomatous response. ...[more]

PMID: 30992086

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