Proteomic analysis of dafachronic acid-associated alterations in Haemonchus contortus
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Haemonchus Contortus (barber Pole Worm)
TISSUE(S): Whole Body, Somatic Cell
DISEASE(S): Parasitic Helminthiasis Infectious Disease
SUBMITTER: 
Tao Wang
LAB HEAD: Robin Beat Gasser
PROVIDER: PXD012878 | Pride | 2019-11-13
REPOSITORIES: Pride
Publications
Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.
Ma Guangxu G Wang Tao T Korhonen Pasi K PK Young Neil D ND Nie Shuai S Ang Ching-Seng CS Williamson Nicholas A NA Reid Gavin E GE Gasser Robin B RB
PLoS pathogens 20190723 7
Here, we discovered an endogenous dafachronic acid (DA) in the socioeconomically important parasitic nematode Haemonchus contortus. We demonstrate that DA promotes larval exsheathment and development in this nematode via a relatively conserved nuclear hormone receptor (DAF-12). This stimulatory effect is dose- and time-dependent, and relates to a modulation of dauer-like signalling, and glycerolipid and glycerophospholipid metabolism, likely via a negative feedback loop. Specific chemical inhibi ...[more]
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