Proteomic analysis of endometrioid and high-grade serous ovarian tumour samples

ABSTRACT: Precision medicine approaches in ovarian cancer require the accurate diagnosis of histotypes. In particular, there is a critical need to distinguish endometroid (EC) from high grade serous (HGSC) carcinomas, which differ greatly in outcomes, genetic predisposition and optimal treatment approaches. Herein, we performed label-free quantitative proteomics on freshly frozen tumour tissues to discover biomarkers that may distinguish EC from HGSC, and then used IHC to validate these using a contemporarily classified cohort of EC and HGSC samples.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary, Ovary Cancer Cell

DISEASE(S): Ovarian Cancer,Ovarian Serous Carcinoma,Endometrioid Ovary Carcinoma

SUBMITTER: Dylan Dieters-Castator  

LAB HEAD: Gilles A. Lajoie

PROVIDER: PXD012998 | Pride | 2019-03-13

REPOSITORIES: Pride