Proteomics

Dataset Information

0

Sperm proteome of CMTM4-deficient mice


ABSTRACT: Cmtm4 Knockout mouse was constructed by CRISPR-Cas9 technology, and the KO mice showed male infertility. A proteomic anlaysis of sperm proteins was performed by comparing KO and WT mice.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus musculus  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Liu FuJun  

LAB HEAD: Liu FuJun

PROVIDER: PXD013092 | Pride | 2019-05-21

REPOSITORIES: Pride

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Publications

Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility.

Liu FuJun F   Liu XueXia X   Liu Xin X   Li Ting T   Zhu Peng P   Liu ZhengYang Z   Xue Hui H   Wang WenJuan W   Yang XiuLan X   Liu Juan J   Han WenLing W  

Molecular & cellular proteomics : MCP 20190313 6


The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family that has been implicated in male reproduction. CMTM4 is an evolutionarily conserved member that is highly expressed in the testis. However, its function in male fertility remains unknown. Here, we demonstrate that CMTM4 is associated with spermatogenesis and sperm quality. Using Western blotting and immunohistochemical analyses, we found CMTM4 expression to be decreased in poor-quality hum  ...[more]

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