Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Hordeum Vulgare (barley)
TISSUE(S): Epithelial Cell
SUBMITTER: Alex von kriegsheim
LAB HEAD: Alex von Kriegsheim
PROVIDER: PXD013116 | Pride | 2020-03-23
REPOSITORIES: Pride
Rodriguez Javier J Haydinger Cameron D CD Peet Daniel J DJ Nguyen Lan K LK von Kriegsheim Alex A
Molecular & cellular proteomics : MCP 20200805 11
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified. Such hydroxylation is currently considered irreversible, necessitating the degradation and re-synthesis of the entire protein to reset the modification. Here we present evidence that the cellular machinery can reverse FIH-mediated asparagine hydroxylation on intact proteins. These data suggest that asparagine hydroxylation i ...[more]