Liver zonation patterns and cell size variability in isolated human hepatocytes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte, Liver
SUBMITTER: 
Christine Wegler
LAB HEAD: Per Artursson
PROVIDER: PXD013142 | Pride | 2021-01-26
REPOSITORIES: Pride
Publications
Hepatocyte size fractionation allows dissection of human liver zonation.
Ölander Magnus M Wegler Christine C Flörkemeier Inken I Treyer Andrea A Handin Niklas N Pedersen Jenny M JM Vildhede Anna A Mateus André A LeCluyse Edward L EL Urdzik Jozef J Artursson Per P
Journal of cellular physiology 20210116 8
Human hepatocytes show marked differences in cell size, gene expression, and function throughout the liver lobules, an arrangement termed liver zonation. However, it is not clear if these zonal size differences, and the associated phenotypic differences, are retained in isolated human hepatocytes, the "gold standard" for in vitro studies of human liver function. Here, we therefore explored size differences among isolated human hepatocytes and investigated whether separation by size can be used t ...[more]
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