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CCT3 acts as upstream of YAP and TFCP2 to be a potential target and tumor biomarker in liver cancer

ABSTRACT: Recently, we've reported that pro-tumorigenic roles of YAP in liver cancer are indispensable of TFCP2 act as upstream to simultaneously control YAP.The aim of this study is to uncover such proteins and evaluate whether the candidates are potential YAP-associated therapeutic target and diagnostic marker Via mass spectrometry, CCT3 was identified to co-interact with YAP and TFCP2, and importantly.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Liver Cancer

SUBMITTER: YA LIU

LAB HEAD: Fenyong Sun

PROVIDER: PXD013143 | Pride | 2019-09-11

REPOSITORIES: Pride

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CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Liu Ya Y Zhang Xiao X Lin Jiafei J Chen Yuxin Y Qiao Yongxia Y Guo Susu S Yang Yueyue Y Zhu Guoqing G Pan Qiuhui Q Wang Jiayi J Sun Fenyong F

Cell death & disease 20190909 9

Although Yes-associated protein (YAP) is very important to liver cancer, its nuclear localisation prevents consideration as a promising therapeutic target and a diagnostic biomarker. Recently, we reported that the protumourigenic roles of YAP in liver cancer are indispensable for transcription factor CP2 (TFCP2) in a Hippo-independent manner; however, proteins that act upstream to simultaneously control YAP and TFCP2 remain unclear. The aim of this study was to uncover such proteins and evaluate ...[more]

PMID: 31501420

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