Human nk cell line LC-MSMS - Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Lymphoma
SUBMITTER: 
zm Li
LAB HEAD: Zhaoming Li
PROVIDER: PXD013285 | Pride | 2019-09-25
REPOSITORIES: Pride
Publications
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
Li Zhaoming Z Zhang Xudong X Xue Weili W Zhang Yanjie Y Li Chaoping C Song Yue Y Mei Mei M Lu Lisha L Wang Yingjun Y Zhou Zhiyuan Z Jin Mengyuan M Bian Yangyang Y Zhang Lei L Wang Xinhua X Li Ling L Li Xin X Fu Xiaorui X Sun Zhenchang Z Wu Jingjing J Nan Feifei F Chang Yu Y Yan Jiaqin J Yu Hui H Feng Xiaoyan X Wang Guannan G Zhang Dandan D Fu Xuefei X Zhang Yuan Y Young Ken H KH Li Wencai W Zhang Mingzhi M
Nature communications 20190916 1
Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive malignancy with a higher prevalence in Asia and South America. However, the molecular genetic mechanisms underlying NKTCL remain unclear. Here, we identify somatic mutations of GNAQ (encoding the T96S alteration of Gαq protein) in 8.7% (11/127) of NKTCL patients, through whole-exome/targeted deep sequencing. Using conditional knockout mice (Ncr1-Cre-Gnaq<sup>fl/fl</sup>), we demonstrate that Gαq deficiency leads to enhanced NK cell ...[more]
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