Proteomics

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THE EFFECTS OF SPACE FLIGHT FACTORS ON THE HUMAN PLASMA PROTEOME, INCLUDING BOTH REAL SPACE MISSIONS AND GROUND-BASED MODEL EXPERIMENTS.


ABSTRACT: The aim of the study was to continue of the proteomic data accumulation on the effects of space flight factors on the human body, including ground-based model experiments. Blood plasma samples were collected from 5 healthy men included in the 21 days head-down bed rest experiment (HDBR) and 5 volunteers participating in a 21 day long dry immersion experiment.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Alexander Brzhozovskiy  

LAB HEAD: Alexey Kononikhin

PROVIDER: PXD013305 | Pride | 2019-07-04

REPOSITORIES: Pride

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Publications

The Effects of Spaceflight Factors on the Human Plasma Proteome, Including Both Real Space Missions and Ground-Based Experiments.

Brzhozovskiy Alexander G AG   Kononikhin Alexey S AS   Pastushkova Lyudmila Ch LC   Kashirina Daria N DN   Indeykina Maria I MI   Popov Igor A IA   Custaud Marc-Antoine MA   Larina Irina M IM   Nikolaev Evgeny N EN  

International journal of molecular sciences 20190629 13


The aim of the study was to compare proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based experiments. LC-MS/MS-based proteomic analysis of blood plasma samples obtained from 13 cosmonauts before and after long-duration (169-199 days) missions on the International Space Station (ISS) and for five healthy men included in 21-day-long head-down bed rest (HDBR) and dry immersion experiments were performed. The semi-quantitative la  ...[more]

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