Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Hela Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Yang Li
LAB HEAD: Jianyuan Zhao
PROVIDER: PXD013309 | Pride | 2019-11-12
REPOSITORIES: Pride
Nature communications 20190607 1
Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In late G<sub>1</sub> and S phases, transketolase-like 1 (TKTL1) is overexpressed and forms stable TKTL1-transketolase heterodimers that accumulate ribose-5-phosphate. This accumulation occurs by asymmetric production of ribose-5-phosphate from the n ...[more]