Dataset Information
Thermal proteome profiling of darobactin in Escherichia coli
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Andre Mateus
LAB HEAD: Mikhail M. Savitski
PROVIDER: PXD013319 | Pride | 2019-10-29
REPOSITORIES: Pride
Publications
A new antibiotic selectively kills Gram-negative pathogens.
Nature 20191120 7787
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens<sup>1,2</sup>. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds<sup>3,4</sup>. As a result, the last class of antibiotics that acted against Gram-negative bacteria was developed in the 1960s<sup>2</sup>. We reason that useful compounds can be found in bacteria that share similar requirements for antibiotics with humans, and focus ...[more]
