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Quantitative proteomic analysis of SUMOylation in renal cortical collecting duct cells after aldosterone stimulation

ABSTRACT: SILAC was employed to investigate the effect of aldosterone stimulation on SUMOylation of cortical collecting duct (mpkCCD) cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell

SUBMITTER: Qi Wu

LAB HEAD: Robert A. Fenton

PROVIDER: PXD013363 | Pride | 2019-10-07

REPOSITORIES: Pride

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SUMOylation Landscape of Renal Cortical Collecting Duct Cells.

Wu Qi Q Aroankins Takwa S TS Cheng Lei L Fenton Robert A RA

Journal of proteome research 20190918 10

Protein post-translational modification by the small ubiquitin-like modifier (SUMO) is a mechanism that allows a diverse response of cells to stress. Five SUMO family members, SUMO1-5, are expressed in mammals. We hypothesized that because kidney epithelial cells are often subject to stresses arising from various physiological conditions, multiple proteins in the kidney will be SUMOylated. Here, we profiled SUMO1- and SUMO2-modified proteins in a polarized epithelial cell model of the renal cort ...[more]

PMID: 31502464

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