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Arabidopsis Hrd1 complex - PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex

ABSTRACT: We are using the immunoprecipitation coupled with mass spectrometry to identify additional components of the Arabidopsis Hrd1-containing ERAD complex

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Whole Body

SUBMITTER: Jianming Li

LAB HEAD: Jianming LI

PROVIDER: PXD013400 | Pride | 2019-08-15

REPOSITORIES: Pride

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PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex.

Lin Liangguang L Zhang Congcong C Chen Yongwu Y Wang Yi Y Wang Dinghe D Liu Xiaolei X Wang Muyang M Mao Juan J Zhang Jianjun J Xing Weiman W Liu Linchuan L Li Jianming J

Nature communications 20190802 1

Endoplasmic reticulum-associated degradation (ERAD) is a unique mechanism to degrade misfolded proteins via complexes containing several highly-conserved ER-anchored ubiquitin ligases such as HMG-CoA reductase degradation1 (Hrd1). Arabidopsis has a similar Hrd1-containing ERAD machinery; however, our knowledge of this complex is limited. Here we report two closely-related Arabidopsis proteins, Protein Associated With Hrd1-1 (PAWH1) and PAWH2, which share a conserved domain with yeast Altered Inh ...[more]

PMID: 31375683

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