Proteomics analysis of the Enterobacter cloacae response to imipenem

ABSTRACT: Recently, we have reported on a highly drug-resistant carbapenemase-producing isolate of Enterobacter cloacae (Nepal et al., Virulence. 2018; 9: 1377-1389). In the present study, we asked the question whether and, if so, how this isolate responds to a sub-inhibitory challenge with the antibiotic imipenem. To answer this question, we applied a SILAC proteomics approach that allowed the quantification of changes in the relative abundance of bacterial protein in response to imipenem. The results show that the investigated E. cloacae isolate mounts a highly specific response to counteract the detrimental effects of imipenem.

INSTRUMENT(S):

ORGANISM(S): Enterobacter Cloacae

SUBMITTER: Sandra Maass  

LAB HEAD: Dörte Becher

PROVIDER: PXD013412 | Pride | 2021-08-10

REPOSITORIES: Pride