Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cerebrospinal Fluid
SUBMITTER: Astrid Guldbrandsen
LAB HEAD: Frode S. Berven
PROVIDER: PXD013449 | Pride | 2020-09-25
REPOSITORIES: Pride
Guldbrandsen Astrid A Lereim Ragnhild Reehorst RR Jacobsen Mari M Garberg Hilde H Kroksveen Ann Cathrine AC Barsnes Harald H Berven Frode S FS
Clinical proteomics 20200918
<h4>Background</h4>Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease and biological heterogeneity, and the lack of standardized assays. Furthermore, verification studies are often based on a low number of proteins from a single discovery experiment in medium-sized cohorts, where antibodies and surrogate peptides may differ, thus only pr ...[more]